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The map shows countries in shades of blue, with the United States and China in darker blue and several African countries in gray.",1.9366197183098592,"data:image\u002Fjpeg;base64,\u002F9j\u002F4AAQSkZJRgABAQAAAQABAAD\u002F2wCEAAoHBwgHBgoICAgLCgoXDhgaDhUNGh0VFREVFxUZGBYVFiEdHysjHR0oHSEWJDUlKC0vMjIyGSI4PTcwPCsxMi8BCgsLDg0OHBAQHDscFhwvLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vL\u002F\u002FAABEIAA0AGAMBIgACEQEDEQH\u002FxAAYAAACAwAAAAAAAAAAAAAAAAAFBgADBP\u002FEACAQAAAGAQUBAAAAAAAAAAAAAAABAgMEBREGEyFBURL\u002FxAAVAQEBAAAAAAAAAAAAAAAAAAAEA\u002F\u002FEABkRAAIDAQAAAAAAAAAAAAAAAAIRAAEDE\u002F\u002FaAAwDAQACEQMRAD8AcG4u1KURH0AEpj6s3CyCCJzypisn0FC0tJDd2okq4FuhKQrIHNtA87A1Oo0+iCnTr6n7zK+TEB7MnEVmCn\u002F\u002F2Q==","#028cc1",568,"(max-width: 1100px) 100vw, 1100px","https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png","https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png?dpr=0.25 275w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png?dpr=0.5 550w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png?dpr=0.75 825w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png 1100w","https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png?dpr=0.25&fm=webp 275w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png?dpr=0.5&fm=webp 550w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png?dpr=0.75&fm=webp 825w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1712143712-madsen-map-edited.png?fm=webp 1100w",1100,[],[4351,4355,4359],{"link":4352},{"__typename":4209,"text":4353,"link":4354},"CONTACT US ",{"id":274},{"link":4356},{"__typename":4209,"text":4357,"link":4358},"Partnering with us ",{"id":179},{"link":4360},{"__typename":4209,"text":337,"link":4361},{"id":339},"You are now leaving Pharmacosmos.com.\nThe website you are about to visit is a\nPharmacosmos subsidiary.",{"yes":4364,"cancel":4365,"proceed":4366},"Yes","Cancel","Do you wish to proceed?",{"global":4368},{"primaryLinks":4369,"ctaLinks":4421,"secondaryLinks":4432,"copyrightText":4442},[4370,4390,4402,4411],{"headline":2493,"links":4371},[4372,4375,4378,4381,4384,4387],{"link":4373},{"__typename":4209,"text":494,"link":4374},{"id":496},{"link":4376},{"__typename":4209,"text":77,"link":4377},{"id":82},{"link":4379},{"__typename":4209,"text":4219,"link":4380},{"id":4159},{"link":4382},{"__typename":4209,"text":401,"link":4383},{"id":403},{"link":4385},{"__typename":4209,"text":711,"link":4386},{"id":715},{"link":4388},{"__typename":4209,"text":4125,"link":4389},{"id":4127},{"headline":2522,"links":4391},[4392,4396,4399],{"link":4393},{"__typename":4209,"text":4394,"link":4395},"Pharmaceutical",{"id":115},{"link":4397},{"__typename":4209,"text":928,"link":4398},{"id":930},{"link":4400},{"__typename":4209,"text":897,"link":4401},{"id":899},{"headline":4258,"links":4403},[4404,4408],{"link":4405},{"__typename":4209,"text":4406,"link":4407},"Clinical trials",{"id":436},{"link":4409},{"__typename":4209,"text":835,"link":4410},{"id":837},{"headline":4412,"links":4413},"NEWS &MEDIA",[4414,4417],{"link":4415},{"__typename":4209,"text":1122,"link":4416},{"id":1124},{"link":4418},{"__typename":4209,"text":4419,"link":4420},"Media",{"id":963},[4422,4427],{"headline":524,"links":4423},[4424],{"link":4425},{"__typename":4209,"text":524,"link":4426},{"id":179},{"headline":1089,"links":4428},[4429],{"link":4430},{"__typename":4209,"text":70,"link":4431},{"id":1091},[4433,4436,4439],{"link":4434},{"__typename":4209,"text":337,"link":4435},{"id":339},{"link":4437},{"__typename":4209,"text":774,"link":4438},{"id":556},{"link":4440},{"__typename":4209,"text":272,"link":4441},{"id":274},"© 2024 PHARMACOSMOS A\u002FS This website contains information on products which is targeted to a wide range of audiences outside US and may contain product details or information otherwise not accessible or valid in your country. Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. PHARMACOSMOS®, Monofer®, CosmoFer®, Diafer®, Uniferon® and Pentahibe® are registered trademarks of Pharmacosmos Holding A\u002FS. All rights reserved.",{"pageId":1245,"page":4444,"linkedinTranslations":4670},{"newsArticlePage":4445,"translation":4664},{"id":1245,"_firstPublishedAt":1247,"hero":4446,"image":4449,"kontainerImage":11,"modularContent":11,"structuredText":4459,"linkedinSettings":11,"deadline":4626,"complianceCode":70,"_seoMetaTags":4627,"showSubscribeToNewsletterOnPage":4663},{"headline":4447,"teaserText":4448},"New study shows that treatment with ferric derisomaltose improves exercise capacity in patients with heart failure with preserved ejection fraction and iron deficiency","Pharmacosmos A\u002FS today announced that results from the IRONMET-HFpEF study have been published in Circulation. The randomized, double-blind, placebo-controlled study found that ferric derisomaltose improved exercise capacity over 12 weeks compared with placebo in patients with heart failure with preserved ejection fraction (HFpEF) and iron deficiency. ",{"responsiveImage":4450},{"alt":70,"aspectRatio":4451,"base64":4452,"bgColor":4453,"height":4275,"sizes":4454,"src":4455,"srcSet":4456,"title":70,"webpSrcSet":4457,"width":4458},1.9038461538461537,"data:image\u002Fjpeg;base64,\u002F9j\u002F4AAQSkZJRgABAQAAAQABAAD\u002F2wCEAAoHBwgHBgoICAgLCgoRDiQWDhgNDhgVFhUVFxQeGCIfFiEaHy0jHR0oHRUWJDUlKC0vMjIyHSI4PTcwPCsxMi8BCgsLDg0OHBAQHDsdFig7Ly8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vLy8vL\u002F\u002FAABEIAA0AGAMBIgACEQEDEQH\u002FxAAYAAACAwAAAAAAAAAAAAAAAAAABgIEBf\u002FEAB4QAAAHAAMBAAAAAAAAAAAAAAABAgMEBREGFDET\u002F8QAFgEBAQEAAAAAAAAAAAAAAAAABAMC\u002F8QAGREAAgMBAAAAAAAAAAAAAAAAAxEAAQIx\u002F9oADAMBAAIRAxEAPwC5yG16iNQZGMdPJHXWEkFWwtZMlBfRWiKpC24RGn0KCLS7DkJTjrMuHFVpYYAivWsnp5oBPQ9Ps3W6U\u002F\u002FZ","#335f84","(max-width: 1188px) 100vw, 1188px","https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg","https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg?dpr=0.25 297w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg?dpr=0.5 594w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg?dpr=0.75 891w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg 1188w","https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg?dpr=0.25&fm=webp 297w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg?dpr=0.5&fm=webp 594w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg?dpr=0.75&fm=webp 891w,https:\u002F\u002Fwww.datocms-assets.com\u002F115772\u002F1793972180-mass-general-brigham.jpg?fm=webp 1188w",1188,{"id":4460,"content":4461},"TiVhrvp9TH-jR-sOqNZMpQ",{"value":4462,"links":4625},{"schema":4463,"document":4464},"dast",{"type":4465,"children":4466},"root",[4467,4484,4497,4501,4505,4514,4518,4525,4529,4532,4537,4551,4555,4559,4562,4567,4572,4575,4580,4591,4593,4622],{"type":4468,"children":4469},"paragraph",[4470,4473,4477,4479,4482],{"type":4471,"value":4472},"span","Iron deficiency affects 50% of people with heart failure and is associated with reduced exercise capacity and poorer quality of life",{"type":4471,"marks":4474,"value":4476},[4475],"superscript","1",{"type":4471,"value":4478},". Heart failure affects approximately 1–2% of adults in developed countries, with prevalence increasing markedly with age",{"type":4471,"marks":4480,"value":4481},[4475],"2",{"type":4471,"value":4483},".",{"type":4468,"children":4485},[4486,4488,4491,4493,4496],{"type":4471,"value":4487},"IRONMET-HFpEF focused on patients with iron deficiency and HFpEF (~50% of all HF patients",{"type":4471,"marks":4489,"value":4490},[4475],"3",{"type":4471,"value":4492},"), a form of heart failure in which the heart pumps out a normal proportion of blood with each beat but can have difficulty relaxing and filling between beats, resulting in fluid congestion. Patients commonly experience breathlessness and difficulty with physical activity, including everyday tasks such as walking or climbing stairs",{"type":4471,"marks":4494,"value":4495},[4475],"4",{"type":4471,"value":4483},{"type":4468,"children":4498},[4499],{"type":4471,"value":4500},"The IRONMET-HFpEF study, sponsored by the National Institutes of Health and conducted at Massachusetts General Hospital in Boston, investigated whether correcting iron deficiency with ferric derisomaltose, an intravenous iron treatment developed and manufactured by Pharmacosmos, could improve exercise capacity in these patients. It enrolled 65 patients at a single center and compared ferric derisomaltose with placebo over 12 weeks. The main measure was peak oxygen uptake, the highest amount of oxygen the body uses during an exercise test. Peak oxygen uptake is a key measure of heart failure disease burden that objectively captures the burden of functional limitation experienced by people with HFpEF.",{"type":4468,"children":4502},[4503],{"type":4471,"value":4504},"At 12 weeks, the adjusted difference between groups in the change in peak oxygen uptake was 1.1 mL\u002Fkg\u002Fmin in favor of ferric derisomaltose (95% confidence interval [CI], 0.2 to 1.9; P=0.02). Patients receiving ferric derisomaltose also showed a greater improvement in the distance walked in six minutes, with a between-group difference of 41.1 meters (95% CI, 9.5 to 72.8; P=0.01).",{"type":4468,"children":4506},[4507,4512],{"type":4471,"marks":4508,"value":4511},[4509,4510],"strong","emphasis","\"In the first study to comprehensively evaluate exercise response patterns to iron repletion in patients with HFpEF and iron deficiency, we found that ferric derisomaltose improved multiple measures of exercise capacity,\" ",{"type":4471,"value":4513},"said principal investigator Gregory Lewis, MD, Director of Heart Failure, Mass General Brigham Heart and Vascular Institute and Professor of Medicine, Harvard Medical School.",{"type":4468,"children":4515},[4516],{"type":4471,"value":4517},"Few studies have examined intravenous iron in HFpEF. IRONMET-HFpEF represents a step towards understanding whether correcting iron deficiency can improve exercise capacity in this less studied patient group. ",{"type":4468,"children":4519},[4520,4523],{"type":4471,"marks":4521,"value":4522},[4509,4510],"\"The improvement we observed in peak VO2 represents a clinically meaningful increment for patients with heart failure,\"",{"type":4471,"value":4524}," said co-principal investigator Rajeev Malhotra, MD, Associate Director of the Cardiopulmonary Exercise Laboratory at the Mass General Brigham Heart and Vascular Institute and Associate Professor of Medicine at Harvard Medical School.",{"type":4468,"children":4526},[4527],{"type":4471,"value":4528},"Research into iron deficiency across different heart failure populations includes Pharmacosmos’ support for IRONMAN  and its ongoing international Phase III trial, ICONIC-HF, involving clinical sites across Europe, Latin America, Asia, Canada and the United States.",{"type":4468,"children":4530},[4531],{"type":4471,"value":70},{"type":4468,"children":4533},[4534],{"type":4471,"marks":4535,"value":4536},[4509],"About the study",{"type":4468,"children":4538},[4539,4541],{"type":4471,"value":4540},"IRONMET-HFpEF was an investigator-initiated, National Heart, Lung, and Blood Institute-sponsored, randomized, double-blind, placebo-controlled trial conducted at Massachusetts General Hospital in Boston. Sixty-five adults with HFpEF and iron deficiency were randomised 2:1 to receive a single 1,000 mg intravenous dose of ferric derisomaltose or placebo. The primary endpoint was change in peak oxygen uptake from baseline to week 12. The study included participants with and without anemia and was registered at ClinicalTrials.gov (NCT04945707). The results were presented November 8 in a Late-breaking Science Session at the American Heart Association Scientific Sessions 2026 in Chicago and published simultaneously in Circulation. ",{"url":4542,"meta":4543,"type":4547,"children":4548},"https:\u002F\u002Fwww.ahajournals.org\u002Fdoi\u002F10.1161\u002FCIRCULATIONAHA.126.084009",[4544],{"id":4545,"value":4546},"target","_blank","link",[4549],{"type":4471,"value":4550},"Link",{"type":4468,"children":4552},[4553],{"type":4471,"value":4554},"The findings are limited by the sample size of 65 patients, single-center design and 12-week follow-up. KCCQ did not differ significantly between groups, and the study was not designed to assess longer-term outcomes such as hospitalization or mortality. In this study, no serious adverse events were related to ferric derisomaltose.",{"type":4468,"children":4556},[4557],{"type":4471,"value":4558},"Pharmacosmos donated the study drug.",{"type":4468,"children":4560},[4561],{"type":4471,"value":70},{"type":4468,"children":4563},[4564],{"type":4471,"marks":4565,"value":4566},[4509,4510],"About Pharmacosmos ",{"type":4468,"children":4568},[4569],{"type":4471,"marks":4570,"value":4571},[4510],"Pharmacosmos A\u002FS is a global leader in carbohydrate chemistry and innovative treatments for iron deficiency and iron deficiency anemia. Building on our foundational expertise in carbohydrate chemistry and cell cycle biology, we develop innovative treatments for unmet patient needs, with a focus on iron metabolism and blood-related disorders. Founded in 1965 and headquartered in Denmark, our team is made up of more than 650 specialists across the UK, Ireland, the Nordics, Germany, Canada, and the USA.",{"type":4468,"children":4573},[4574],{"type":4471,"value":70},{"type":4468,"children":4576},[4577],{"type":4471,"marks":4578,"value":4579},[4509],"Contact",{"type":4468,"children":4581},[4582,4584],{"type":4471,"value":4583},"Christian Lundquist Madsen, Vice President Global Marketing & Communication\n+45 5948 5959  |  ",{"url":4585,"meta":4586,"type":4547,"children":4588},"mailto:clm@pharmacosmos.com",[4587],{"id":4545,"value":4546},[4589],{"type":4471,"value":4590},"clm@pharmacosmos.com",{"type":4592},"thematicBreak",{"type":4594,"style":4595,"children":4596},"list","numbered",[4597,4604,4610,4616],{"type":4598,"children":4599},"listItem",[4600],{"type":4468,"children":4601},[4602],{"type":4471,"value":4603},"Lewis G, et al. Circulation 2026, DOI: 10.1161\u002FCIRCULATIONAHA.126.084009",{"type":4598,"children":4605},[4606],{"type":4468,"children":4607},[4608],{"type":4471,"value":4609},"Khan MS, et al. Nat Rev Cardiol. 2024 for overall HF epidemiology",{"type":4598,"children":4611},[4612],{"type":4468,"children":4613},[4614],{"type":4471,"value":4615},"Campbell P, Rutten FH, Lee MMY, Hawkins NM, Petrie MC. Heart failure with preserved ejection fraction: everything the clinician needs to know. The Lancet. 2024;403:1083–1092",{"type":4598,"children":4617},[4618],{"type":4468,"children":4619},[4620],{"type":4471,"value":4621},"Ejection Fraction Heart Failure Measurement | American Heart Association ",{"type":4468,"children":4623},[4624],{"type":4471,"value":70},[],"2026-11-29",[4628,4632,4635,4637,4639,4641,4643,4645,4647,4649,4651,4653,4655,4657,4659,4661],{"tag":4629,"attributes":11,"content":4630,"__typename":4631},"title","Pharmacosmos - Pharmacosmos","Tag",{"tag":4633,"attributes":4634,"content":11,"__typename":4631},"meta",{"property":14,"content":62},{"tag":4633,"attributes":4636,"content":11,"__typename":4631},{"name":18,"content":62},{"tag":4633,"attributes":4638,"content":11,"__typename":4631},{"name":21,"content":22},{"tag":4633,"attributes":4640,"content":11,"__typename":4631},{"property":25,"content":22},{"tag":4633,"attributes":4642,"content":11,"__typename":4631},{"name":28,"content":22},{"tag":4633,"attributes":4644,"content":11,"__typename":4631},{"property":31,"content":1262},{"tag":4633,"attributes":4646,"content":11,"__typename":4631},{"property":35,"content":1265},{"tag":4633,"attributes":4648,"content":11,"__typename":4631},{"property":39,"content":1268},{"tag":4633,"attributes":4650,"content":11,"__typename":4631},{"name":47,"content":1262},{"tag":4633,"attributes":4652,"content":11,"__typename":4631},{"property":53,"content":54},{"tag":4633,"attributes":4654,"content":11,"__typename":4631},{"property":57,"content":101},{"tag":4633,"attributes":4656,"content":11,"__typename":4631},{"property":61,"content":62},{"tag":4633,"attributes":4658,"content":11,"__typename":4631},{"property":65,"content":1279},{"tag":4633,"attributes":4660,"content":11,"__typename":4631},{"property":69,"content":70},{"tag":4633,"attributes":4662,"content":11,"__typename":4631},{"name":73,"content":74},false,{"goTo":4665,"news":4666,"date":4667,"deadlinePopOut":4668,"subscribeToNewsletterText":4669},"Go to","Corporate News and Press Releases","Date","To learn about this article, please contact our media relations, Christian Lundquist Madsen (clm@pharmacosmos.com)","Subscribe to our newsletter",{"linkedinWidgetHeadline":4671,"linkedinHeadline":4672,"linkedinLink":4673},"Explore our LinkedIn posts","Join us on LinkedIn",{"__typename":4674,"id":4675,"url":4676,"text":4677,"target":4546,"download":4663},"ExternalLinkRecord","DmaalAE7TbuKM9iF_ycG3w","https:\u002F\u002Fdk.linkedin.com\u002Fcompany\u002Fpharmacosmos","Stay updated with exciting job opportunities and the latest updates at Pharmacosmos.",1794153512631]